International journal of pharmaceutics
Nov 24, 2025
Over the past two decades, a diverse array of ultrasonic and acoustic elastic-wave techniques has been developed to non-destructively assess macro- and micro-scale properties of compressed Oral Solid Dosage (OSD) forms. These methods are increasingly...
Understanding a drug's plasma half-life is essential in guiding dosage regimens and optimizing therapeutic outcomes, particularly in the early stages of drug development. By using published pharmacokinetic data from Food Animal Residue Avoidance Data...
Reliable prediction of drug solubility in supercritical carbon dioxide (scCO₂) is crucial for the efficient design of pharmaceutical processes, including particle engineering and supercritical fluid-based extraction. Given that experimental determina...
Journal of chemical information and modeling
Nov 4, 2025
Understanding the intricate relationships between genes and drugs is crucial for advancing drug discovery. However, biological experiments aimed at identifying gene-drug associations are typically time-consuming and inefficient, leading to significan...
Modeling and analysis of the lyophilization process for low-temperature drying of pharmaceutical compounds was evaluated via a hybrid model that combines mass transfer and machine learning. We investigated the predictive accuracy of three machine lea...
The liquid and solid formulations of self-nano-emulsifying drug delivery systems (SNEDDS) have garnered significant attention in the pharmaceutical field for their ability to enhance the solubility and absorption of hydrophobic drugs. While both liqu...
Journal of computer-aided molecular design
Oct 24, 2025
Accurate prediction of a drug molecule's toxicity is a critical step in pharmaceutical research, offering the potential to reduce experimental costs, mitigate adverse effects, and accelerate drug development. Traditional computational methods often r...
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and its most common application, MALD-MS imaging (MSI), are widely used techniques in the analysis of intact biomolecules. In the context of pharmaceutical research, MALDI-MSI i...
Surface-enhanced Raman spectroscopy (SERS) is regarded as a powerful tool for rapid drug identification in the liquid phase. However, the implementation of SERS for drug detection in the liquid phase remains constrained by two critical limitations: i...
In drug discovery, metabolite identification data are used to identify metabolic soft spots in research molecules to facilitate reduced metabolism in subsequently designed compounds. In addition, knowledge about exact metabolite structures enables th...
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