AIMC Topic: Repressor Proteins

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Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer.

Cancer research Apr 14, 2023
UNLABELLED: Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying mol...
Humans Machine Learning Computer Simulation Male Gene Expression Profiling Gene Regulatory Networks Bayes Theorem Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Prostatic Neoplasms Drug Resistance, Neoplasm Transcription, Genetic Repressor Proteins Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-myb Androstenes
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Humans Male Cell Line, Tumor RNA, Messenger Gene Expression Regulation, Neoplastic Gene Expression Blotting, Western Prostatic Neoplasms Fibronectins Down-Regulation Receptors, Androgen Oligonucleotide Array Sequence Analysis Repressor Proteins Androgens Dihydrotestosterone
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