AIMC Topic: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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TFEB/LAMP2 contributes to PM-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.

Journal of environmental sciences (China) Oct 5, 2023
Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathol...
Animals Mice Air Pollutants Astrocytes alpha-Synuclein Autophagy Lysosomes Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Lysosomal-Associated Membrane Protein 2 Particulate Matter Mice, Inbred ICR
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Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer.

Cancer research Apr 14, 2023
UNLABELLED: Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying mol...
Humans Machine Learning Computer Simulation Male Gene Expression Profiling Gene Regulatory Networks Bayes Theorem Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Prostatic Neoplasms Drug Resistance, Neoplasm Transcription, Genetic Repressor Proteins Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-myb Androstenes
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NNAlign: a platform to construct and evaluate artificial neural network models of receptor-ligand interactions.

Nucleic acids research Jul 3, 2017
Peptides are extensively used to characterize functional or (linear) structural aspects of receptor-ligand interactions in biological systems, e.g. SH2, SH3, PDZ peptide-recognition domains, the MHC membrane receptors and enzymes such as kinases and ...
Humans Neural Networks, Computer Software Algorithms Peptides Protein Binding Databases, Protein Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Internet Forkhead Transcription Factors Amino Acid Sequence Ligands Cell Cycle Proteins Binding Sites Trans-Activators Sequence Alignment HLA-A1 Antigen HLA-B7 Antigen HLA-B8 Antigen HLA-DRB1 Chains
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