AIMC Topic: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma.

Scientific reports Jul 13, 2025
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecular subtype...
Gene Expression Regulation, Neoplastic Transcription Factors Protein Interaction Maps Gene Regulatory Networks Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Mutation Glioma Basic Helix-Loop-Helix Transcription Factors Prognosis Biomarkers, Tumor Humans Brain Neoplasms Gene Expression Profiling
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TFEB/LAMP2 contributes to PM-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.

Journal of environmental sciences (China) Oct 5, 2023
Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathol...
Lysosomal-Associated Membrane Protein 2 Particulate Matter Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Mice, Inbred ICR Mice Astrocytes Animals Autophagy Air Pollutants alpha-Synuclein Lysosomes
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Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer.

Cancer research Apr 14, 2023
UNLABELLED: Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying mol...
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Prostatic Neoplasms Gene Regulatory Networks Bayes Theorem Repressor Proteins Proto-Oncogene Proteins c-ets Drug Resistance, Neoplasm Transcription, Genetic Machine Learning Computer Simulation Male Gene Expression Profiling Humans Androstenes Proto-Oncogene Proteins c-myb
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NNAlign: a platform to construct and evaluate artificial neural network models of receptor-ligand interactions.

Nucleic acids research Jul 3, 2017
Peptides are extensively used to characterize functional or (linear) structural aspects of receptor-ligand interactions in biological systems, e.g. SH2, SH3, PDZ peptide-recognition domains, the MHC membrane receptors and enzymes such as kinases and ...
HLA-DRB1 Chains HLA-B8 Antigen Databases, Protein Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Internet Forkhead Transcription Factors Peptides Protein Binding Algorithms Neural Networks, Computer Trans-Activators Software Sequence Alignment Humans HLA-A1 Antigen Cell Cycle Proteins HLA-B7 Antigen Amino Acid Sequence Binding Sites Ligands
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