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Sequence Homology, Amino Acid

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WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning.

PLoS computational biology
The rapid advancement of technology in genomics and targeted genetic manipulation has made comparative biology an increasingly prominent strategy to model human disease processes. Predicting orthology relationships between species is a vital componen...

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification.

Immunogenetics
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented ...