AIMC Topic: Silent Mutation
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MFDSMC: Accurate Identification of Cancer-Driver Synonymous Mutations Using Multiperspective Feature Representation Learning.
Journal of chemical information and modeling
Jun 5, 2025
Synonymous mutations do not change amino acid sequences, but they can drive cancer by influencing splicing, mRNA structure, translation efficiency, and other molecular mechanisms. Although driver synonymous mutations are significantly outnumbered by ...
usDSM: a novel method for deleterious synonymous mutation prediction using undersampling scheme.
Briefings in bioinformatics
Sep 2, 2021
Although synonymous mutations do not alter the encoded amino acids, they may impact protein function by interfering with the regulation of RNA splicing or altering transcript splicing. New progress on next-generation sequencing technologies has put t...
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