BACKGROUND & AIMS: The incidence of early-onset colorectal cancer (EOCRC; diagnosed before age 50 years) continues to increase, now standing as the leading cause of cancer-related deaths in young men. Screening participation in young adults remains l... read more
OBJECTIVES: Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder leading to chronic obstructive pulmonary disease (COPD). Emphysema is the major structural damage visible on CT scans. However, there is little knowledge on the association ... read more
Epigenetic macromolecular enzyme complexes tightly regulate gene expression at the chromatin level and have recently been found to colocalize with RNA splicing machinery during active transcription; however, the precise functional consequences of the... read more
Neural networks : the official journal of the International Neural Network Society
Dec 9, 2025
Continual learning is a crucial capability for deep-learning models in real-world applications, enabling them to acquire new knowledge while avoiding catastrophic forgetting. With advances in large-scale pre-trained models, recent methods have begun ... read more
Right ventricular myocardial infarction (RVMI) is associated with higher in-hospital morbidity and mortality. Cardiac magnetic resonance (CMR) imaging provides crucial pathological information for diagnosis and/or treatment of RVMI. Segmentation of R... read more
Regulatory toxicology and pharmacology : RTP
Dec 9, 2025
Pesticides are suspected to cause health effects in humans, but human-based data on their toxicity are often insufficient to establish associations and quantify risks. We reviewed literature on trichlorfon and investigated methodological aspects of r... read more
INTRODUCTION: Gastric cancer remains a major global health burden, with high mortality driven by late-stage diagnoses that limit treatment options and reduce survival. Current diagnostic methods such as endoscopy and biopsy are invasive, resource-int... read more
ETHNOPHARMACOLOGICAL RELEVANCE: Gelsemium elegans Benth. (G. elegans) is a highly toxic medicinal plant traditionally used to treat pain and inflammatory disorders. Accidental ingestion or misuse often causes severe poisoning and death, primarily due... read more
International journal of pharmaceutics
Dec 9, 2025
Exosomes are small, membrane-enclosed vesicles that can originate from a variety of sources and contain a wealth of material. They are involved in physiological processes such as cell-cell communication, cell migration, and anti-tumor immunity, and a... read more
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