Multicenter integration analysis of TRP channels revealed potential mechanisms of immunosuppressive microenvironment activation and identified a machine learning-derived signature for improving outcomes in gliomas.

Journal: CNS neuroscience & therapeutics
Published Date: Jul 1, 2024

Abstract

AIM: This study aimed to explore the mechanisms of transient receptor potential (TRP) channels on the immune microenvironment and develop a TRP-related signature for predicting prognosis, immunotherapy response, and drug sensitivity in gliomas.

Authors

  • Yuntao Li
    Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yonggang Zhang
    Department of Radiology, The First People's Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.
  • Shi Feng
    Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.
  • Hua Zhu
    School of Kinesiology, Shanghai University of Sport Shanghai, China.
  • Ying Xing
    Automation School, Beijing University of Posts and Telecommunications, Beijing 100876, China.
  • Xiaoxing Xiong
    Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
  • Qianxue Chen
    Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

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