AIMC Topic: TRPV Cation Channels

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Machine learning and multi-omics integration reveal TRPV2 as a central regulator in bicuspid aortic valve calcification.

Biochemical and biophysical research communications Oct 21, 2025
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...
Aortic Valve Stenosis Aortic Valve MicroRNAs Multiomics Calcinosis Heart Valve Diseases Calcium Channels Aortic Valve Disease Osteogenesis Bicuspid Aortic Valve Disease RNA, Long Noncoding Animals Gene Expression Profiling Gene Regulatory Networks Mice Humans TRPV Cation Channels Machine Learning
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Integrative Computational Approaches for TRPV1 Ion Channel Inhibitor Discovery: An Integrated Machine Learning, Drug Repurposing and Molecular Simulation Approach.

Journal of chemical information and modeling Aug 21, 2025
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a key mediator of pain and inflammation, making it a crucial target for developing new analgesics. Despite progress in understanding TRPV1's role, novel modulators that effectively i...
Machine Learning Molecular Docking Simulation Drug Discovery Humans Molecular Dynamics Simulation TRPV Cation Channels Drug Repositioning
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Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation.

International journal of molecular sciences Feb 6, 2025
Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel critical for maintaining intracellular Ca homeostasis and is essential in regulating immune responses, metabolic processes, and signal transduction. Recent studies...
Antiviral Agents Mice Influenza, Human Influenza A virus TRPV Cation Channels Orthomyxoviridae Infections Small Molecule Libraries Humans Machine Learning Molecular Docking Simulation Drug Discovery Animals
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Peripheral Blood Mononuclear Cell Biomarkers for Major Depressive Disorder: A Transcriptomic Approach.

Depression and anxiety Oct 3, 2024
Major depressive disorder (MDD) is a complex condition characterized by persistent depressed mood, loss of interest or pleasure, loss of energy or fatigue, and, in severe case, recurrent thoughts of death. Despite its prevalence, reliable diagnostic...
TRPV Cation Channels Middle Aged Case-Control Studies Leukocytes, Mononuclear Female Gene Expression Profiling Depressive Disorder, Major Humans Adult Transcriptome Biomarkers Male
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Discovery of novel TRPV1 modulators through machine learning-based molecular docking and molecular similarity searching.

Chemical biology & drug design Jul 25, 2023
The transient receptor potential vanilloid 1 (TRPV1) channel belongs to the transient receptor potential channel superfamily and participates in many physiological processes. TRPV1 modulators (both agonists and antagonists) can effectively inhibit pa...
Humans TRPV Cation Channels Molecular Dynamics Simulation Ligands Machine Learning Molecular Docking Simulation
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Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning.

Journal of chemical information and modeling Dec 31, 2018
Here we report PPB2 as a target prediction tool assigning targets to a query molecule based on ChEMBL data. PPB2 computes ligand similarities using molecular fingerprints encoding composition (MQN), molecular shape and pharmacophores (Xfp), and subst...
Drug Discovery TRPV Cation Channels Machine Learning Polypharmacology Databases, Chemical Software
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Multicenter integration analysis of TRP channels revealed potential mechanisms of immunosuppressive microenvironment activation and identified a machine learning-derived signature for improving outcomes in gliomas.

CNS neuroscience & therapeutics Jul 1, 2024
AIM: This study aimed to explore the mechanisms of transient receptor potential (TRP) channels on the immune microenvironment and develop a TRP-related signature for predicting prognosis, immunotherapy response, and drug sensitivity in gliomas.
Mice Glioma Transient Receptor Potential Channels Male TRPV Cation Channels Machine Learning Female Humans Brain Neoplasms Animals Tumor Microenvironment
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Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Pain Jul 1, 2018
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. Howeve...
TRPA1 Cation Channel Humans Machine Learning Pain Threshold TRPV Cation Channels Pain Capsaicin High-Throughput Nucleotide Sequencing Genotype Hot Temperature Genetic Association Studies
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