Deep Learning-based Brain Age Prediction in Patients With Schizophrenia Spectrum Disorders.

Journal: Schizophrenia bulletin
Published Date:

Abstract

BACKGROUND AND HYPOTHESIS: The brain-predicted age difference (brain-PAD) may serve as a biomarker for neurodegeneration. We investigated the brain-PAD in patients with schizophrenia (SCZ), first-episode schizophrenia spectrum disorders (FE-SSDs), and treatment-resistant schizophrenia (TRS) using structural magnetic resonance imaging (sMRI).

Authors

  • Woo-Sung Kim
    Department of Psychiatry, Jeonbuk National University Medical School, 20, Geonji-ro, Jeonju, 54907, Republic of Korea.
  • Da-Woon Heo
    Department of Artificial Intelligence, Korea University, Seoul, Korea.
  • Junyeong Maeng
    Department of Artificial Intelligence, Korea University, Seoul, Korea.
  • Jie Shen
    Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, China; Pharmacy School, Wannan Medical College, Wuhu, Anhui 241002, China; Department of Clinical Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, China; Anhui Provincial Engineering Research Center for Polysaccharides Drugs, Wannan Medical College, Wuhu, Anhui 241001, China.
  • Uyanga Tsogt
    Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.
  • Soyolsaikhan Odkhuu
    Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.
  • Xuefeng Zhang
    Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
  • Sahar Cheraghi
    Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.
  • Sung-Wan Kim
    Department of Psychiatry, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea.
  • Byung-Joo Ham
    Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Korea.
  • Fatima Zahra Rami
    Department of Psychiatry, Jeonbuk National University Medical School, 20, Geonji-ro, Jeonju, 54907, Republic of Korea.
  • Jing Sui
    The Mind Research Network, Albuquerque, NM 87106, USA; Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Chae Yeong Kang
    Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
  • Heung-Il Suk
    Biomedical Research Imaging Center (BRIC) and Department of Radiology, University of North Carolina, Chapel Hill, NC, 27599, USA, hsuk@med.unc.edu.
  • Young-Chul Chung
    Department of Psychiatry, Jeonbuk National University Medical School, 20, Geonji-ro, Jeonju, 54907, Republic of Korea. chungyc@jbnu.ac.kr.