[Preparation of Baicalein Liposome-Lyophilized Powder and Its Pharmacokinetics Study].
Journal:
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Published Date:
Nov 1, 2015
Abstract
OBJECTIVE: To prepare baicalein liposome-lyophilized powder, and to investigate the particle size distribution, encapsulation efficiency, stability, in vitro release and in vivo pharmacokirietics in rats. METHODs: Baicalein liposome was prepared by the ethanol injection, the encapsulation efficiency was measured by column chromatography, glucose, lactose and mannitol were selected as lyoprotectants. Pharmacokinetics study in rats was carried out by oral administration and analysis of rats pharmacokinetic parameters.