AIMC Topic: Liposomes
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Roadmap for Commercial Nanomedicine Development: Integrating Quality by Design Principles with Pharmaceutical Nanotechnology.
Molecular pharmaceutics
Jul 16, 2025
Integrating Quality by Design (QbD) principles into nanomedicine development marks a paradigm shift from traditional empirical approaches to more systematic risk-based strategies. This review explores the application of QbD in pharmaceutical nanotech...
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Journal of nanobiotechnology
Jul 5, 2025
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in t...
Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.
ACS nano
Jun 16, 2025
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...
Next-generation cancer therapeutics: unveiling the potential of liposome-based nanoparticles through bioinformatics.
Mikrochimica acta
Jun 16, 2025
Cancer remains one of the most deadly diseases in the world, requiring constant growth and improvements in therapeutic strategies. Traditional cancer treatments, such as chemotherapy, radiotherapy, and surgery, have limitations like off-target releas...
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.
BMC cancer
May 12, 2025
Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer cell types. We synthesized optimized niosome NPs (NPs) with high solubility and capacity for solanin...
Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.
Drug delivery
Mar 3, 2025
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
'Applications of machine learning in liposomal formulation and development'.
Pharmaceutical development and technology
Jan 11, 2025
Machine learning (ML) has emerged as a transformative tool in drug delivery, particularly in the design and optimization of liposomal formulations. This review focuses on the intersection of ML and liposomal technology, highlighting how advanced algo...
Deep Learning for the Accurate Prediction of Triggered Drug Delivery.
IEEE transactions on nanobioscience
Jan 2, 2025
The need to mitigate the adverse effects of chemotherapy has driven the exploration of innovative drug delivery approaches. One emerging trend in cancer treatment is the utilization of Drug Delivery Systems (DDSs), facilitated by nanotechnology. Nano...
Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery.
Nature communications
Dec 30, 2024
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial i...
Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non-melanoma skin cancer treatment.
International journal of pharmaceutics
Dec 13, 2024
The current study focused on the development of crosslinked hydrogel microneedle patches (cHMNs) incorporating 5-FU-hydroxypropyl beta-cyclodextrin inclusion complex-loaded flexible PEGylated liposomes (5-FU-HPβCD-loaded FP-LPs) to enhance treatment ...
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