AIMC Topic: Freeze Drying
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Theoretical investigations on analysis and optimization of freeze drying of pharmaceutical powder using machine learning modeling of temperature distribution.
Scientific reports
Jan 6, 2025
This study investigates the application of various neural network-based models for predicting temperature distribution in freeze drying process of biopharmaceuticals. For heat-sensitive biopharmaceutical products, freeze drying is preferred to preven...
A deep learning approach to perform defect classification of freeze-dried product.
International journal of pharmaceutics
Jan 3, 2025
Cosmetic inspection of freeze-dried products is an important part of the post-manufacturing quality control process. Traditionally done by human visual inspection, this method poses typical challenges and shortcomings that can be addressed with innov...
Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals.
AAPS PharmSciTech
Jun 25, 2024
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not onl...
Improved freeze drying efficiency by ice nucleation proteins with ice morphology modification.
Food research international (Ottawa, Ont.)
Dec 14, 2017
This study aims to use ice nucleation proteins (INPs) as a novel approach to improve the efficiency of freeze drying process and investigate the related mechanism of ice morphology. Our results show that INPs can significantly improve freeze drying e...
On the Design of a Fuzzy Logic-Based Control System for Freeze-Drying Processes.
Journal of pharmaceutical sciences
Sep 28, 2016
This article is focused on the design of a fuzzy logic-based control system to optimize a drug freeze-drying process. The goal of the system is to keep product temperature as close as possible to the threshold value of the formulation being processed...
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.
Journal of pharmaceutical sciences
Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
Lyophilized nasal swabs for COVID-19 detection by ATR-FTIR spectroscopy: Machine learning-based approach.
Biophysical chemistry
Sep 1, 2025
The COVID-19 pandemic continues to pose challenges for global health. The disease burden and diagnostic pressure has forced scientists to explore alternate diagnostic tools beyond the standard PCR testing. One such promising tool is the use of spectr...
Digital image technology based on PCA and SVM for detection and recognition of foreign bodies in lyophilized powder.
Technology and health care : official journal of the European Society for Engineering and Medicine
Jan 1, 2020
BACKGROUND: Digital image technology has made great progress in the field of foreign body detection and classification, which is of great help to drug purity extraction and impurity analysis and classification.
[Preparation of Baicalein Liposome-Lyophilized Powder and Its Pharmacokinetics Study].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Nov 1, 2015
OBJECTIVE: To prepare baicalein liposome-lyophilized powder, and to investigate the particle size distribution, encapsulation efficiency, stability, in vitro release and in vivo pharmacokirietics in rats. METHODs: Baicalein liposome was prepared by t...
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