Metabolic signatures derived from whole-brain MR-spectroscopy identify early tumor progression in high-grade gliomas using machine learning.

Journal: Journal of neuro-oncology
Published Date: Aug 24, 2024

Abstract

PURPOSE: Recurrence for high-grade gliomas is inevitable despite maximal safe resection and adjuvant chemoradiation, and current imaging techniques fall short in predicting future progression. However, we introduce a novel whole-brain magnetic resonance spectroscopy (WB-MRS) protocol that delves into the intricacies of tumor microenvironments, offering a comprehensive understanding of glioma progression to inform expectant surgical and adjuvant intervention.

Authors

  • Cameron A Rivera
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA. car909@med.miami.edu.
  • Shovan Bhatia
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Alexis A Morell
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Lekhaj C Daggubati
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Martin A Merenzon
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
  • Sulaiman A Sheriff
    Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Evan Luther
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Jay Chandar
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Adam S Levy
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Ashley R Metzler
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Chandler N Berke
    Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Mohammed Goryawala
    Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Eric A Mellon
    Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Rita G Bhatia
    Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Natalya Nagornaya
    Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Gaurav Saigal
    Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Macarena I de la Fuente
    Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.
  • Ricardo J Komotar
    Department of Neurological Surgery, University of Miami, Miami, FL, USA.
  • Michael E Ivan
    Department of Neurological Surgery, University of Miami, Miami, FL, USA.
  • Ashish H Shah
    Department of Neurological Surgery, University of Miami, Miami, FL, USA.

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