The impact of multicentric datasets for the automated tumor delineation in primary prostate cancer using convolutional neural networks on F-PSMA-1007 PET.

Journal: Radiation oncology (London, England)
PMID: 39113123

Abstract

PURPOSE: Convolutional Neural Networks (CNNs) have emerged as transformative tools in the field of radiation oncology, significantly advancing the precision of contouring practices. However, the adaptability of these algorithms across diverse scanners, institutions, and imaging protocols remains a considerable obstacle. This study aims to investigate the effects of incorporating institution-specific datasets into the training regimen of CNNs to assess their generalization ability in real-world clinical environments. Focusing on a data-centric analysis, the influence of varying multi- and single center training approaches on algorithm performance is conducted.

Authors

  • Julius C Holzschuh
    Department of Radiation Oncology, Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany; Faculty of Computer Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. Electronic address: julius.holzschuh@uniklinik-freiburg.de.
  • Michael Mix
    Department of Nuclear Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Martin T Freitag
    Division of Radiology, German Cancer Research Center (dkfz), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
  • Tobias Hölscher
    Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
  • Anja Braune
    Department of Nuclear Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
  • Jörg Kotzerke
    German Cancer Consortium, Heidelberg, Germany.
  • Alexis Vrachimis
    Department of Nuclear Medicine, German Oncology Center - University Hospital of the European University, Limassol, Cyprus.
  • Paul Doolan
    Department of Radiation Oncology, German Oncology Center - University Hospital of the European University, Limassol, Cyprus.
  • Harun Ilhan
    Department of Nuclear Medicine, University Hospital - Ludwig-Maximilians-Universität, Munich, Germany.
  • Ioana M Marinescu
    Department of Radiation Oncology, Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.
  • Simon K B Spohn
    Department of Radiation Oncology, Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany; Faculty of Medicine - University of Freiburg, Berta-Ottenstein-Programme, Freiburg, Germany.
  • Tobias Fechter
    Division of Medical Physics, Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Dejan Kuhn
    Department of Radiation Oncology, Medical Center - University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany; Division of Medical Physics, Department of Radiation Oncology, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
  • Christian Gratzke
    Department of Urology, LMU Munich, Munich, Germany. Electronic address: christian.gratzke@med.uni-muenchen.de.
  • Radu Grosu
    Cyber-Physical Systems Division, Institute of Computer Engineering and Faculty of Informatics, Technical University of Vienna, Vienna, Austria; Department of Computer Science, State University of New York at Stony Brook, NY, USA.
  • Anca-Ligia Grosu
    German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.
  • C Zamboglou
    Department of Radiation Oncology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, German Cancer Consortium (DKTK), Partner Site DKTK, Freiburg, Germany.

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