AIMC Topic: Niacinamide

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Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.

BMC cancer May 21, 2025
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
Humans Retrospective Studies Aged Deep Learning Pilot Projects Early Detection of Cancer Male Middle Aged Oligopeptides Niacinamide Prostatic Neoplasms Radiopharmaceuticals Fluorine Radioisotopes Bone Neoplasms Positron Emission Tomography Computed Tomography
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Prediction of adverse pathology in prostate cancer using a multimodal deep learning approach based on [F]PSMA-1007 PET/CT and multiparametric MRI.

European journal of nuclear medicine and molecular imaging Feb 19, 2025
PURPOSE: Accurate prediction of adverse pathology (AP) in prostate cancer (PCa) patients is crucial for formulating effective treatment strategies. This study aims to develop and evaluate a multimodal deep learning model based on [F]PSMA-1007 PET/CT ...
Deep Learning Multimodal Imaging Positron Emission Tomography Computed Tomography Male Middle Aged Oligopeptides Niacinamide Multiparametric Magnetic Resonance Imaging Prostatic Neoplasms Retrospective Studies Fluorine Radioisotopes Aged Humans
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Integration of 3D-QSAR, molecular docking, and machine learning techniques for rational design of nicotinamide-based SIRT2 inhibitors.

Computational biology and chemistry Oct 10, 2024
Selective inhibitors of sirtuin-2 (SIRT2) are increasingly recognized as potential therapeutics for cancer and neurodegenerative diseases. Derivatives of 5-((3-amidobenzyl)oxy)nicotinamides have been identified as some of the most potent and selectiv...
Quantitative Structure-Activity Relationship Niacinamide Molecular Docking Simulation Drug Design Enzyme Inhibitors Sirtuin 2 Molecular Structure Humans Machine Learning
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The impact of multicentric datasets for the automated tumor delineation in primary prostate cancer using convolutional neural networks on F-PSMA-1007 PET.

Radiation oncology (London, England) Aug 7, 2024
PURPOSE: Convolutional Neural Networks (CNNs) have emerged as transformative tools in the field of radiation oncology, significantly advancing the precision of contouring practices. However, the adaptability of these algorithms across diverse scanner...
Niacinamide Fluorine Radioisotopes Oligopeptides Image Processing, Computer-Assisted Neural Networks, Computer Humans Positron-Emission Tomography Prostatic Neoplasms Algorithms Radiopharmaceuticals Datasets as Topic Male
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Preparing pathological data to develop an artificial intelligence model in the nonclinical study.

Scientific reports Mar 8, 2023
Artificial intelligence (AI)-based analysis has recently been adopted in the examination of histological slides via the digitization of glass slides using a digital scanner. In this study, we examined the effect of varying the staining color tone and...
Artificial Intelligence Research Niacinamide Algorithms Eosine Yellowish-(YS)
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Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy.

Journal of pharmaceutical and biomedical analysis Jun 4, 2018
The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine-nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC...
Niacinamide Spectrum Analysis, Raman Drug Combinations Spectroscopy, Fourier Transform Infrared Carbamazepine Crystallization Drug Compounding Neural Networks, Computer Polyvinyls Chemistry, Pharmaceutical Least-Squares Analysis Absorption, Physicochemical Machine Learning Ibuprofen Polyethylene Glycols Calibration
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An ecofriendly green liquid chromatographic method for simultaneous determination of nicotinamide and clindamycin phosphate in pharmaceutical gel for acne treatment.

Journal of food and drug analysis Dec 1, 2016
A new green micellar liquid chromatographic method was developed and validated for the quantitative estimation of nicotinamide (NICO) and clindamycin phosphate (CLD) in bulk and pharmaceutical gel formulation. The analytes are well resolved in less t...
Limit of Detection Acne Vulgaris Chemistry, Pharmaceutical Pharmaceutical Preparations Niacinamide Reproducibility of Results Hydrogen-Ion Concentration Chromatography, Liquid Drug Stability Clindamycin
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