The pentafluorosulfanyl group (-SF) is one of the most promising fluorinated functional groups, recently developed as an alternative to the trifluoromethyl group (-CF) in drug design. Fluorine-18 allows researchers to investigate activity and biodis...
Cancer imaging : the official publication of the International Cancer Imaging Society
Aug 19, 2025
OBJECTIVE: This study aimed to construct a multimodal imaging deep learning (DL) model integrating mpMRI and F-PSMA-PET/CT for the prediction of extraprostatic extension (EPE) in prostate cancer, and to assess its effectiveness in enhancing the diagn...
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
European journal of nuclear medicine and molecular imaging
Feb 19, 2025
PURPOSE: Accurate prediction of adverse pathology (AP) in prostate cancer (PCa) patients is crucial for formulating effective treatment strategies. This study aims to develop and evaluate a multimodal deep learning model based on [F]PSMA-1007 PET/CT ...
PURPOSE: Convolutional Neural Networks (CNNs) have emerged as transformative tools in the field of radiation oncology, significantly advancing the precision of contouring practices. However, the adaptability of these algorithms across diverse scanner...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Apr 23, 2021
Coronary F-sodium fluoride (F-NaF) PET and CT angiography-based quantitative plaque analysis have shown promise in refining risk stratification in patients with coronary artery disease. We combined both of these novel imaging approaches to develop an...
AJNR. American journal of neuroradiology
Jun 4, 2020
BACKGROUND AND PURPOSE: Cortical amyloid quantification on PET by using the standardized uptake value ratio is valuable for research studies and clinical trials in Alzheimer disease. However, it is resource intensive, requiring co-registered MR imagi...
PURPOSE: F-NaF PET/CT imaging of bone metastases is confounded by tracer uptake in benign diseases, such as osteoarthritis. The goal of this work was to develop an automated bone lesion classification algorithm to classify lesions in NaF PET/CT image...
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
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