Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder.
Journal:
Journal of affective disorders
PMID:
39284527
Abstract
BACKGROUNDS: Major depressive disorder (MDD) is a pervasive mental and mood disorder with complicated and heterogeneous etiology. Mitophagy, a selective autophagy of cells, specifically eliminates dysfunctional mitochondria. The mitochondria dysfunction in the astrocytes is regarded as a critical pathogenetic mechanism of MDD. However, studies on the mitophagy of astrocytes in MDD are scarce. To explore the impact of mitophagy on the astrocytes, we used bioinformatic methods to analyze the correlation between astrocyte-related genes and mitophagy-related genes in MDD.