AIMC Topic: Astrocytes
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Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions.
Journal of Alzheimer's disease : JAD
Jun 2, 2025
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) formed by aggregates of hyperphosphorylated tau proteins. It presents a formidable global health challenge, prompting the exploration of inno...
The Role of Hydrogen Sulfide in the Localization and Structural-Functional Organization of p53 Following Traumatic Brain Injury: Development of a YOLO Model for Detection and Quantification of Apoptotic Nuclei.
International journal of molecular sciences
May 24, 2025
Traumatic brain injury (TBI) triggers a cascade of molecular and cellular disturbances, including apoptosis, inflammation, and destabilization of neuronal connections. The transcription factor p53 plays a pivotal role in regulating cell fate followin...
Neuron-astrocyte associative memory.
Proceedings of the National Academy of Sciences of the United States of America
May 23, 2025
Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how neurons, synapses, and astrocytes might collectivel...
Supervised and unsupervised learning reveal heroin-induced impairments in astrocyte structural plasticity.
Science advances
Apr 30, 2025
Astrocytes regulate synaptic activity across large brain territories via their complex, interconnected morphology. Emerging evidence supports the involvement of astrocytes in shaping relapse to opioid use through morphological rearrangements in the n...
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.
Cell
Apr 8, 2025
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to ex...
Situation-Based Neuromorphic Memory in Spiking Neuron-Astrocyte Network.
IEEE transactions on neural networks and learning systems
Jan 7, 2025
Mammalian brains operate in very special surroundings: to survive they have to react quickly and effectively to the pool of stimuli patterns previously recognized as danger. Many learning tasks often encountered by living organisms involve a specific...
Arithmetic abilities of SNP systems with astrocytes producing calcium.
Neural networks : the official journal of the International Neural Network Society
Nov 26, 2024
Are the membrane systems able of performing arithmetic operations? In the last dozen years, there were published several implementations of the arithmetic operations based on membrane systems by using all available topologies (cell-like, tissue-like,...
Deep-Learning-Based Segmentation of Cells and Analysis (DL-SCAN).
Biomolecules
Oct 23, 2024
With the recent surge in the development of highly selective probes, fluorescence microscopy has become one of the most widely used approaches to studying cellular properties and signaling in living cells and tissues. Traditionally, microscopy image ...
Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder.
Journal of affective disorders
Sep 14, 2024
BACKGROUNDS: Major depressive disorder (MDD) is a pervasive mental and mood disorder with complicated and heterogeneous etiology. Mitophagy, a selective autophagy of cells, specifically eliminates dysfunctional mitochondria. The mitochondria dysfunct...
Machine learning approach for recognition and morphological analysis of isolated astrocytes in phase contrast microscopy.
Scientific reports
Apr 29, 2024
Astrocytes are glycolytically active cells in the central nervous system playing a crucial role in various brain processes from homeostasis to neurotransmission. Astrocytes possess a complex branched morphology, frequently examined by fluorescent mic...
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