AIMC Topic: Mitochondria
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Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy.
Scientific reports
Aug 7, 2025
Diabetic nephropathy (DN) is a kidney disease. Mitochondrial and endoplasmic reticulum stress (ERS) significantly contribute to diabetic nephropathy (DN), although the precise mechanisms involved have not yet been fully understood. The objective of t...
Adaptive-learning physics-assisted light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics.
Nature communications
Aug 4, 2025
Long-term and high-spatiotemporal-resolution 3D imaging of living cells remains an unmet challenge for super-resolution microscopy, owing to the noticeable phototoxicity and limited scanning speed. While emerging light-field microscopy can mitigate t...
Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma.
Journal for immunotherapy of cancer
Jul 31, 2025
BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited resp...
AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact.
The Journal of cell biology
Jul 30, 2025
Membrane contact sites (MCSs) establish organelle interactomes in cells to enable communication and exchange of materials. Volume EM (vEM) is ideally suited for MCS analyses, but semantic segmentation of large vEM datasets remains challenging. Recent...
Exploration and validation of the prognostic value of mitophagy and mitochondrial dynamics-related genes in cervical cancer.
Scientific reports
Jul 10, 2025
The mechanisms underlying mitophagy and mitochondrial dynamics (MD) in cervical cancer (CC), a disease with a high mortality rate, remain poorly understood. This study aimed to assess the prognostic significance of these processes in CC. Mendelian ra...
Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability.
Journal of the American Chemical Society
Jul 8, 2025
Mitochondrial fission is controlled by dynamin-like proteins, the dysregulation of which is correlated with diverse diseases. Fission dynamin-like proteins are GTP hydrolysis-driven mechanoenzymes that self-oligomerize into helical structures that co...
Identification and single-cell analysis of prognostic genes related to mitochondrial and neutrophil extracellular traps in bladder cancer.
Scientific reports
Jul 4, 2025
The development of bladder cancer (BLCA) is associated with mitochondrial dysfunction and neutrophil extracellular traps (NETs); however, the relationship between mitochondrial function and NET formation in BLCA remains poorly understood. In this stu...
Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.
Scientific reports
Jul 1, 2025
Mitochondria play a crucial role in cellular respiration and immune responses. Mitochondrial DNA (mtDNA) haplogroups and variants have been associated with various diseases, including COVID-19. This study analyzed complete mtDNA sequences from 467 Br...
Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia.
Scientific reports
Jul 1, 2025
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction.
Scientific reports
Jul 1, 2025
Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using ...
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