A machine learning model revealed that exosome small RNAs may participate in the development of breast cancer through the chemokine signaling pathway.

Journal: BMC cancer
PMID: 39574053

Abstract

BACKGROUND: Exosome small RNAs are believed to be involved in the pathogenesis of cancer, but their role in breast cancer is still unclear. This study utilized machine learning models to screen for key exosome small RNAs and analyzed and validated them.

Authors

  • Jun-Luan Mo
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, P. R. China.
  • Xi Li
  • Lin Lei
    Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, P. R. China.
  • Ji Peng
    Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, P. R. China.
  • Xiong-Shun Liang
    Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, P. R. China.
  • Hong-Hao Zhou
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, P. R. China.
  • Zhao-Qian Liu
    Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, P. R. China.
  • Wen-Xu Hong
    Shenzhen Center for Chronic Disease Control, Shenzhen, 518020, P. R. China. szbloodcenter@hotmail.com.
  • Ji-Ye Yin
    Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, P. R. China. yinjiye@csu.edu.cn.

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