Prognostic Significance and Associations of Neural Network-Derived Electrocardiographic Features.

Journal: Circulation. Cardiovascular quality and outcomes
PMID: 39540287

Abstract

BACKGROUND: Subtle, prognostically important ECG features may not be apparent to physicians. In the course of supervised machine learning, thousands of ECG features are identified. These are not limited to conventional ECG parameters and morphology. We aimed to investigate whether neural network-derived ECG features could be used to predict future cardiovascular disease and mortality and have phenotypic and genotypic associations.

Authors

  • Arunashis Sau
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Antônio H Ribeiro
    Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. antonio-ribeiro@ufmg.br.
  • Kathryn A McGurk
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Libor Pastika
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Nikesh Bajaj
    Imperial College London, National Heart & Lung Institute, London, W12 0NN, UK.
  • Mehak Gurnani
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Ewa Sieliwonczyk
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Konstantinos Patlatzoglou
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Maddalena Ardissino
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Jun Yu Chen
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Huiyi Wu
    Imperial College London, National Heart & Lung Institute, London, W12 0NN, UK.
  • Xili Shi
    Imperial College London, National Heart & Lung Institute, London, W12 0NN, UK.
  • Katerina Hnatkova
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Sean L Zheng
    National Heart and Lung Institute (A.S., K.A.M., L.P., N.B., M.G., E. Sieliwonczyk, K.P., M.A., J.Y.C., H.W., X.S., K.H., S.Z., D.B.K., N.S.P., M.M., J.S.W., F.S.N.), Imperial College London, United Kingdom.
  • Annie Britton
    Research Department of Epidemiology and Public Health, University College London, United Kingdom (A.B., M.S.).
  • Martin Shipley
    Research Department of Epidemiology and Public Health, University College London, United Kingdom (A.B., M.S.).
  • Irena Andršová
    Department of Internal Medicine and Cardiology, University Hospital Brno and Masaryk University, Czech Republic (I.A., T.N., M.M.).
  • Tomáš Novotný
    Department of Internal Medicine and Cardiology, University Hospital Brno and Masaryk University, Czech Republic (I.A., T.N., M.M.).
  • Ester C Sabino
    Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, 05403-000, Brazil.
  • Luana Giatti
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Sandhi M Barreto
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Jonathan W Waks
    Harvard-Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.
  • Daniel B Kramer
    Richard A. and Susan F. Smith Center for Outcomes Research, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Danilo Mandic
    Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom. Electronic address: d.mandic@imperial.ac.uk.
  • Nicholas S Peters
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.
  • Declan P O'Regan
    MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
  • Marek Malík
    Department of Thoracic Surgery, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovakia.
  • James S Ware
    National Heart & Lung Institute & MRC London Institute of Medical Sciences, Imperial College London, London W12 0HS, UK.
  • Antonio Luiz P Ribeiro
    Hospital das Clínicas and Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190 - sala 533/Universidade Federal de Minas Gerais (UFMG), Belo Horizonte - MG, Brazil. Electronic address: tom@hc.ufmg.br.
  • Fu Siong Ng
    National Heart and Lung Institute, Hammersmith Campus, Imperial College London, 72 Du Cane Road, W12 0HS, London, UK.

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