The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.

Journal: Asian Pacific journal of cancer prevention : APJCP
PMID: 39733410

Abstract

BACKGROUND: Glioblastoma (GBM) is the most aggressive cancer in the central nervous system in glial cells. Finding novel biomarkers in GBM offers numerous advantages that can contribute to early detection, personalized treatment, improved patient outcomes, and advancements in cancer research and drug development. Integrating machine learning with RNAseq data in medicine holds significant potential for identifying novel biomarkers in various diseases, including cancer.

Authors

  • Ghazaleh Khalili-Tanha
    Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Nima Khalili-Tanha
    Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52Campus Drive, Saskatoon, SK S7N 5B4, Canada.
  • Masoumeh Farahani
    Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mostafa Rezaei-Tavirani
    Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Elham Nazari
    Proteomics Research Center, System Biology Institute, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Elham.Nazari@sbmu.ac.ir.

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