Pathomics-based machine learning models for predicting pathological complete response and prognosis in locally advanced rectal cancer patients post-neoadjuvant chemoradiotherapy: insights from two independent institutional studies.

Journal: BMC cancer
PMID:

Abstract

BACKGROUND: Accurate prediction of pathological complete response (pCR) and disease-free survival (DFS) in locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy (NCRT) is essential for formulating effective treatment plans. This study aimed to construct and validate the machine learning (ML) models to predict pCR and DFS using pathomics.

Authors

  • Yiyi Zhang
    Guangxi Key Laboratory of Power System Optimization and Energy Technology, Guangxi University, Nanning 530004, China. yiyizhang@gxu.edu.cn.
  • Ying Huang
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
  • Meifang Xu
    Zhejiang University International Hospital, Hangzhou, Zhejiang Province 310000, China.
  • Jiazheng Zhuang
    Department of Gastrointestinal Surgery, The Quanzhou First Hospital Affiliated of Fujian Medical University, Quanzhou, China.
  • Zhibo Zhou
    School of Computer Science and Engineering, Beihang University, Beijing, China.
  • Shaoqing Zheng
    Fujian Medical University, Fuzhou, China.
  • Bingwang Zhu
    Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Guoxian Guan
    Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. fjxhggx@163.com.
  • Hong Chen
    Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Xing Liu
    School of Food Science and Engineering, Hainan University 58 Renmin Avenue Haikou 570228 China zhangzeling@hainanu.edu.cn benchao312@hainanu.edu.cn xuhuan.hnu@foxmail.com qichen@hainanu.edu.cn sunzhichang11@163.com hmcao@hainanu.edu.cn.