Can knowledge-based planning models validated on ethnically diverse patients lead to global standardisation of external beam radiation therapy for locally advanced cervix cancer?

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PMID: 39709028

Abstract

BACKGROUND AND PURPOSE: Knowledge-based planning (KBP) can consistently and efficiently create high-quality Volumetric Arc Therapy (VMAT) plans for cervix cancer. This study describes the cross-validation of two KBP models on geographically distinct populations and their comparison to manual plans from 67 centers. The purpose was to determine the universal applicability of a generic KBP model.

Authors

  • Jeevanshu Jain
    Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Kharghar, Navi Mumbai, Maharashtra, India. Electronic address: jjain@actrec.gov.in.
  • Monica Serban
    Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada.
  • Marianne Sanggaard Assenholt
    Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark.
  • Varsha Hande
    Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Kharghar, Navi Mumbai, Maharashtra, India.
  • Jamema Swamidas
    Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
  • Yvette Seppenwoolde
    Department of Radiation Therapy, ErasmusMC Cancer Centre, Rotterdam, The Netherlands.
  • Joanne Alfieri
    Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec.
  • Kari Tanderup
    Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark.
  • Supriya Chopra
    Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

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