Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways.

Journal: European journal of medical research
PMID: 39696629

Abstract

BACKGROUND: Pyroptosis, a specific type of programmed cell death, which has become a significant factor to Parkinson's disease (PD). Concurrently, long non-coding RNAs (lncRNAs) have garnered attention for their regulatory roles in neurodegenerative disorders. This study was designed to ascertain the key lncRNAs in pyroptosis pathways of PD and elucidate their regulatory mechanisms.

Authors

  • Lili Ma
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Yue Liu
    School of Athletic Performance, Shanghai University of Sport, Shanghai, China.
  • Yajing Ren
    School of Medical and Life Sciences, Chengdu University of TCM, Cheng du City, 611137, Sichuan Province, China.
  • Na Mi
    Department of Neurology, Chi Feng Municipal Hospital, Chi Feng City, 024000, Inner Mongolia Autonomous Region, China.
  • Jing Fang
    Department of Information Engineering, Nanchang Hangkong University, Nanchang, Jiangxi, 330063, China.
  • Rui Bao
    Department of Rehabilitation, The Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang Province, China.
  • Xiuzhi Xu
    General Medical Department, Heilongjiang Provincial Hospital, Harbin, 150036, Heilongjiang Province, China.
  • Hongjia Zhang
  • Ying Tang
    Department of Ultrasound, Tianjin First Central Hospital, NanKai University, Tianjin, 300192, China. drtang2002@aliyun.com.

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