AIMC Topic: Pyroptosis
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Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure.
Hereditas
Aug 8, 2025
BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response....
Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis.
Scientific reports
Jul 16, 2025
Chronic low back pain (cLBP ) is a common condition that affects the quality of life, can be caused by disc degeneration, facet arthropathy, myofascial pain, sacroiliac joint pain, spondyloarthropathies, and nociplastic pain etc. Research suggests th...
Identification and experimental validation of BMX as a crucial PANoptosis‑related gene for immune response in Spinal Cord Injury.
PloS one
Jul 15, 2025
Spinal cord injury (SCI) is a debilitating neurological condition that severely impacts motor, sensory, and autonomic functions, leading to significant challenges in patient quality of life and imposing substantial economic burdens on society. PANopt...
Identification and analysis of pyroptosis-related key genes in heart failure.
Journal of cardiothoracic surgery
Jul 14, 2025
BACKGROUND: Pyroptosis plays a pivotal role in the pathogenesis of Heart Failure (HF). However, the current understanding of how pyroptosis-related genes (PRGs) influence HF is scarce. This study aimed to explore the link between PRGs and HF based on...
LncRNAs regulates cell death in osteosarcoma.
Scientific reports
Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis.
Scientific reports
Jul 1, 2025
Atherosclerosis (AS), the leading cause of cardiovascular diseases, is a chronic inflammatory disorder involving lipid metabolism, immune dysregulation, and cell death. Pyroptosis, a form of inflammatory programmed cell death, is implicated in AS pro...
Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning.
Molecular immunology
May 2, 2025
Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular d...
A morphology and secretome map of pyroptosis.
Molecular biology of the cell
Apr 9, 2025
Pyroptosis represents one type of programmed cell death. It is a form of inflammatory cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated membrane pore formation. Caspase-1 initiates the inflammatory response (through ...
Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.
Scientific reports
Feb 27, 2025
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an ischemic stroke event. However, an in-depth mechanistic understanding of their connection remains limited. ...
Deep learning-based image classification reveals heterogeneous execution of cell death fates during viral infection.
Molecular biology of the cell
Jan 22, 2025
Cell fate decisions, such as proliferation, differentiation, and death, are driven by complex molecular interactions and signaling cascades. While significant progress has been made in understanding the molecular determinants of these processes, hist...
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