Subtyping strokes using blood-based protein biomarkers: A high-throughput proteomics and machine learning approach.

Journal: European journal of clinical investigation
PMID:

Abstract

BACKGROUND: Rapid diagnosis of stroke and its subtypes is critical in early stages. We aimed to discover and validate blood-based protein biomarkers to differentiate ischemic stroke (IS) from intracerebral haemorrhage (ICH) using high-throughput proteomics.

Authors

  • Shubham Misra
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Praveen Singh
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Shantanu Sengupta
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Manoj Kushwaha
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Zuhaibur Rahman
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Divya Bhalla
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Pumanshi Talwar
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Manabesh Nath
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Rahul Chakraborty
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • Pradeep Kumar
    Wits Advanced Drug Delivery Platform Research Unit, Faculty of Health Sciences, School of Therapeutic Sciences, Department of Pharmacy and Pharmacology , University of the Witwatersrand, Johannesburg , 7 York Road , Parktown 2193 , South Africa.
  • Amit Kumar
    Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.
  • Praveen Aggarwal
    Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Achal K Srivastava
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Awadh K Pandit
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Dheeraj Mohania
    Department of Dr. RP Centre, All India Institute of Medical Sciences, New Delhi, India.
  • Kameshwar Prasad
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Nishant K Mishra
    Department of Neurology, Yale University School of Medicine, New Haven, CT, United States of America.
  • Deepti Vibha
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.