AIMC Topic: Matrix Metalloproteinase 9
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Subtyping strokes using blood-based protein biomarkers: A high-throughput proteomics and machine learning approach.
European journal of clinical investigation
Dec 10, 2024
BACKGROUND: Rapid diagnosis of stroke and its subtypes is critical in early stages. We aimed to discover and validate blood-based protein biomarkers to differentiate ischemic stroke (IS) from intracerebral haemorrhage (ICH) using high-throughput prot...
Matrix metalloproteinase 9 expression and glioblastoma survival prediction using machine learning on digital pathological images.
Scientific reports
Jul 2, 2024
This study aimed to apply pathomics to predict Matrix metalloproteinase 9 (MMP9) expression in glioblastoma (GBM) and investigate the underlying molecular mechanisms associated with pathomics. Here, we included 127 GBM patients, 78 of whom were rando...
Discovery of biomarkers in the psoriasis through machine learning and dynamic immune infiltration in three types of skin lesions.
Frontiers in immunology
May 13, 2024
INTRODUCTION: Psoriasis is a chronic skin disease characterized by unique scaling plaques. However, during the acute phase, psoriatic lesions exhibit eczematous changes, making them difficult to distinguish from atopic dermatitis, which poses challen...
The effect of thalidomide on the invasive ability of gastric cancer cells by regulating miR-524-5p/FSTL1.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 20, 2023
This study aimed to investigate the effect of thalidomide (Thal) regulating microRNA (miR)-524-5p/follistatin-like protein 1 (FSTL1) on the invasion ability of gastric cancer cells. For this purpose, real-time fluorescent quantitative PCR (RT-qPCR) w...
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.
Journal of ethnopharmacology
Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.
Pharmacological reports : PR
Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
Neoplasm Metastasis
MAP Kinase Signaling System
ADAM Proteins
Mice, SCID
Humans
Animals
Antineoplastic Agents
Cell Line, Tumor
Membrane Proteins
Neoplasm Invasiveness
Cell Proliferation
Pancreatic Neoplasms
Propofol
Matrix Metalloproteinase 9
Cell Movement
Matrix Metalloproteinase 2
Apoptosis
Xenograft Model Antitumor Assays
Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis.
Clinical therapeutics
Dec 26, 2017
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic...
Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.
The Kaohsiung journal of medical sciences
Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
bcl-Associated Death Protein
bcl-X Protein
Cartilage, Articular
Animals
Matrix Metalloproteinase 3
Male
Interleukin-1beta
Rats, Sprague-Dawley
Primary Cell Culture
NF-kappa B
Apoptosis
Saponins
Achyranthes
Matrix Metalloproteinase 9
Caspase 3
bcl-2-Associated X Protein
Tumor Suppressor Protein p53
Anti-Inflammatory Agents, Non-Steroidal
Plant Extracts
Chondrocytes
Gene Expression Regulation
Plant Roots
Rats
Proliferating Cell Nuclear Antigen
Inflammation
Cyclooxygenase 2
Signal Transduction
Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.
Oxidative medicine and cellular longevity
Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Reactive Oxygen Species
NF-kappa B
Anti-Inflammatory Agents
Matrix Metalloproteinase 9
Intercellular Adhesion Molecule-1
Antioxidants
Inflammation
Signal Transduction
Angiogenesis Inhibitors
NF-E2-Related Factor 2
Angiogenesis Inducing Agents
Neovascularization, Pathologic
Heme Oxygenase-1
Glutathione
Basidiomycota
Endothelial Cells
Humans
Tumor Necrosis Factor-alpha
Molecular mechanisms of suberoylanilide hydroxamic acid in the inhibition of TGF-β1-mediated canine corneal fibrosis.
Veterinary ophthalmology
Nov 12, 2015
OBJECTIVE: To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-indep...
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