AIMC Topic: Glial Fibrillary Acidic Protein
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Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.
Journal of neurology
Jun 25, 2025
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.
Fluorescence 'turn-on' sensing of glial fibrillary acidic protein using graphene oxide-quenched copper nanoclusters.
Mikrochimica acta
Mar 26, 2025
This study introduces a fluorescence based sensing platform made to detect glial fibrillary acidic protein (GFAP), a critical biomarker associated with glioblastoma and other astrocytic malignancies. Leveraging the unique optical properties of copper...
Subtyping strokes using blood-based protein biomarkers: A high-throughput proteomics and machine learning approach.
European journal of clinical investigation
Dec 10, 2024
BACKGROUND: Rapid diagnosis of stroke and its subtypes is critical in early stages. We aimed to discover and validate blood-based protein biomarkers to differentiate ischemic stroke (IS) from intracerebral haemorrhage (ICH) using high-throughput prot...
Assessing polyomic risk to predict Alzheimer's disease using a machine learning model.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Nov 7, 2024
INTRODUCTION: Alzheimer's disease (AD) is the most common form of dementia in the elderly. Given that AD neuropathology begins decades before symptoms, there is a dire need for effective screening tools for early detection of AD to facilitate early i...
Deep Learning-Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure.
Toxicologic pathology
Sep 20, 2022
As regulators of homeostasis, astrocytes undergo morphological changes after injury to limit the insult in central nervous system (CNS). Trimethyltin (TMT) is a known neurotoxicant that induces reactive astrogliosis in rat CNS. To evaluate the degree...
Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.
Frontiers in immunology
Feb 4, 2022
BACKGROUND: Inclusion of cerebrospinal fluid (CSF) oligoclonal IgG bands (OCGB) in the revised McDonald criteria increases the sensitivity of diagnosis when dissemination in time (DIT) cannot be proven. While OCGB negative patients are unlikely to de...
Ketofol as an Anesthetic Agent in Patients With Isolated Moderate to Severe Traumatic Brain Injury: A Prospective, Randomized Double-blind Controlled Trial.
Journal of neurosurgical anesthesiology
May 13, 2021
BACKGROUND: The effects of ketofol (propofol and ketamine admixture) on systemic hemodynamics and outcomes in patients undergoing emergency decompressive craniectomy for traumatic brain injury (TBI) are unknown and explored in this study.
Comparative study on the effects of cigarette smoke exposure, ethanol consumption and association: Behavioral parameters, apoptosis, glial fibrillary acid protein and S100β immunoreactivity in different regions of the rat hippocampus.
Alcohol (Fayetteville, N.Y.)
Aug 23, 2018
Exposure to cigarette smoke and ethanol are proposed to trigger neurotoxicity, apoptosis, and to impair neuronal signaling. However, it is little known how the combination of both might trigger astrogliosis and the morphological changes capable of af...
[Effects of treatment on ultrastructure of olfactory bulb and GFAP expression in mice with Parkinson's disease].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion
Oct 12, 2018
OBJECTIVE: To observe the effects of treatment on the ultrastructure of olfactory bulb and the expression of substantia nigra glial fibrillary acidic protein (GFAP) in mice with Parkinson's disease (PD) induced by lipopolysaccharide (LPS), and to pr...
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