Identification of key biomarkers for predicting atherosclerosis progression in polycystic ovary syndrome via bioinformatics analysis and machine learning.

Journal: Computers in biology and medicine
Published Date:

Abstract

OBJECTIVE: Polycystic ovary syndrome (PCOS) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular diseases such as atherosclerosis (AS). This study attempted to explore key biomarkers for predicting AS in patients with PCOS and to investigate the role of immune cell infiltration in this process.

Authors

  • Wenjing Zhang
    Department of Pharmacy, Shanghai Changhai Hospital, Naval Medical University, Shanghai, People's Republic of China.
  • Yalin Wu
    Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
  • Yalin Yuan
    Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
  • Leigang Wang
    Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
  • Bing Yu
    Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key Laboratory of Animal Disease-resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Disease-resistant Nutrition of Sichuan Province, Ya'an, 625014, China.
  • Xin Li
    Veterinary Diagnostic Center, Shanghai Animal Disease Control Center, Shanghai, China.
  • Zhong Yao
    Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
  • Bin Liang
    Image Processing Center, Beihang University, Beijing 100191, People's Republic of China. Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People's Republic of China.