TET2 gene mutation status associated with poor prognosis of transition zone prostate cancer: a retrospective cohort study based on whole exome sequencing and machine learning models.

Journal: Frontiers in endocrinology
PMID: 40297177

Abstract

BACKGROUND: Prostate cancer (PCa) in the transition zone (TZ) is uncommon and often poses challenges for early diagnosis, but its genomic determinants and therapeutic vulnerabilities remain poorly characterized.

Authors

  • Yutong Wang
    Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Ailing Yu
    Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Ziping Gao
    Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Xiaoying Yuan
    Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, Liaoning, China.
  • Xiaochen Du
    College of Humanities and Social Sciences, Dalian Medical University, Dalian, Liaoning, China.
  • Peng Shi
  • Haoyun Guan
    Second Clinical College, Dalian Medical University, Dalian, Liaoning, China.
  • Shuang Wen
    Department of Pathology, Dalian Friendship Hospital, Dalian, China.
  • Honglong Wang
    Department of Pathology, Dalian Friendship Hospital, Dalian, China.
  • Liang Wang
    Information Department, Dazhou Central Hospital, Dazhou 635000, China.
  • Bo Fan
    Department of Bioengineering, University of California-San Francisco Berkeley Joint Program, Room A-C106-B, 1 Irving St, San Francisco, CA, 94143, USA.
  • Zhiyu Liu
    Department of Aerospace and Mechanical Engineering , University of Notre Dame , Notre Dame , Indiana 46556 , United States.

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