AIMC Topic: Proto-Oncogene Proteins

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TET2 gene mutation status associated with poor prognosis of transition zone prostate cancer: a retrospective cohort study based on whole exome sequencing and machine learning models.

Frontiers in endocrinology Apr 14, 2025
BACKGROUND: Prostate cancer (PCa) in the transition zone (TZ) is uncommon and often poses challenges for early diagnosis, but its genomic determinants and therapeutic vulnerabilities remain poorly characterized.
Aged Humans Biomarkers, Tumor Male Machine Learning DNA-Binding Proteins Prognosis Exome Sequencing Retrospective Studies Proto-Oncogene Proteins Middle Aged Dioxygenases Prostatic Neoplasms Mutation
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Direct identification of ALK and ROS1 fusions in non-small cell lung cancer from hematoxylin and eosin-stained slides using deep learning algorithms.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Sep 3, 2022
Anaplastic lymphoma kinase (ALK) and ROS oncogene 1 (ROS1) gene fusions are well-established key players in non-small cell lung cancer (NSCLC). Although their frequency is relatively low, their detection is important for patient care and guides thera...
Humans Deep Learning Lung Neoplasms Proto-Oncogene Proteins Eosine Yellowish-(YS) Hematoxylin Carcinoma, Non-Small-Cell Lung Protein-Tyrosine Kinases In Situ Hybridization, Fluorescence Anaplastic Lymphoma Kinase Gene Rearrangement Oncogene Proteins, Fusion
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Biologically informed deep neural network for prostate cancer discovery.

Nature Sep 22, 2021
The determination of molecular features that mediate clinically aggressive phenotypes in prostate cancer remains a major biological and clinical challenge. Recent advances in interpretability of machine learning models as applied to biomedical proble...
Cell Cycle Proteins Proto-Oncogene Proteins Receptor, Fibroblast Growth Factor, Type 1 Male Deep Learning Prostatic Neoplasms Drug Resistance, Neoplasm Tumor Suppressor Protein p53 Receptors, Androgen Humans Reproducibility of Results
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Prospective identification of hematopoietic lineage choice by deep learning.

Nature methods Feb 20, 2017
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in their shape and movement characteristics. We present a deep neural network that prospectively predicts lineage choice in differentiating primary hematopoi...
Time-Lapse Imaging Image Processing, Computer-Assisted Hematopoietic Stem Cells Area Under Curve Gene Knock-In Techniques Cell Differentiation Mice, Mutant Strains Trans-Activators Biomarkers Cell Lineage Neural Networks, Computer Animals Proto-Oncogene Proteins Machine Learning Male
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Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors.

Frontiers in bioscience (Landmark edition) Feb 21, 2024
BACKGROUND: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: (), (), and (). CCM1 and...
Carrier Proteins Protein Isoforms Receptors, Progesterone Humans Proto-Oncogene Proteins Deep Learning Hemangioma, Cavernous, Central Nervous System Transcription Factors
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Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children.

Journal of clinical research in pediatric endocrinology Dec 1, 2015
OBJECTIVE: There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NG...
Humans Diabetes Mellitus, Type 1 Adolescent Lipocalin-2 Female Acute-Phase Proteins Child Lipocalins Albuminuria Male Diabetic Nephropathies Proto-Oncogene Proteins
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The effect of anaesthetic management on neutrophil gelatinase associated lipocalin (NGAL) levels after robotic surgical oncology.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology Jan 1, 2015
PURPOSE: The main objective of this study was to compare the effect of two anaesthetic techniques (general vs combined) on plasma levels of NGAL (Neutrophil Gelatinase Associated Lipocalin) after robotic urogenital oncosurgery. The secondary objectiv...
Acute Kidney Injury Anesthesia, Epidural Female Gynecologic Surgical Procedures Lipocalin-2 Aged Urologic Surgical Procedures Lipocalins Surgery, Computer-Assisted Acute-Phase Proteins Humans Romania Time Factors Creatinine Robotics Proto-Oncogene Proteins Prospective Studies Male Treatment Outcome Urogenital Neoplasms Biomarkers Anesthesia, General Middle Aged Longitudinal Studies Incidence
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