Assessing the cardioprotective effects of exercise in APOE mouse models using deep learning and photon-counting micro-CT.

Journal: PloS one
PMID: 40208877

Abstract

BACKGROUND: The allelic variations of the apolipoprotein E (APOE) gene play a critical role in regulating lipid metabolism and significantly impact cardiovascular disease risk (CVD). This study aimed to evaluate the impact of exercise on cardiac structure and function in mouse models expressing different APOE genotypes using photon-counting computed tomography (PCCT) and deep learning-based segmentation.

Authors

  • Alex J Allphin
    Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
  • Rohan Nadkarni
    Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
  • Zay Y Han
    Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America.
  • Darin P Clark
  • Ketan B Ghaghada
    Department of Radiology, Baylor College of Medicine, Houston, Texas, United States of America.
  • Alexandra Badea
    Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America.
  • Cristian T Badea

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