AIMC Topic: Apolipoproteins E
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Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Assessing the cardioprotective effects of exercise in APOE mouse models using deep learning and photon-counting micro-CT.
PloS one
Apr 10, 2025
BACKGROUND: The allelic variations of the apolipoprotein E (APOE) gene play a critical role in regulating lipid metabolism and significantly impact cardiovascular disease risk (CVD). This study aimed to evaluate the impact of exercise on cardiac stru...
Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia.
Translational psychiatry
Jan 21, 2025
Existing dementia prediction models using non-neuroimaging clinical measures have been limited in their ability to identify disease. This study used machine learning to re-examine the diagnostic potential of clinical measures for dementia. Data was s...
Assessing polyomic risk to predict Alzheimer's disease using a machine learning model.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Nov 7, 2024
INTRODUCTION: Alzheimer's disease (AD) is the most common form of dementia in the elderly. Given that AD neuropathology begins decades before symptoms, there is a dire need for effective screening tools for early detection of AD to facilitate early i...
Tackling APOE's structural challenges via in silico modeling in the era of neural networks: Can AlphaFold II help circumvent the problem of lacking full-length protein structure?
Archives of biochemistry and biophysics
Oct 22, 2024
The APOE gene, encoding apolipoprotein E, is a predictor of longevity and age-related diseases. Despite numerous genetic studies, the data on molecular mechanisms by which apolipoprotein E affects the human phenotype remain incomplete due to the stru...
Predicting conversion to Alzheimer's disease in individuals with Mild Cognitive Impairment using clinically transferable features.
Scientific reports
Sep 16, 2022
Patients with Mild Cognitive Impairment (MCI) have an increased risk of Alzheimer's disease (AD). Early identification of underlying neurodegenerative processes is essential to provide treatment before the disease is well established in the brain. He...
A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jun 6, 2022
INTRODUCTION: To test the utility of the "A/T/N" system in the Chinese population, we study core Alzheimer's disease (AD) biomarkers in a newly established Chinese cohort.
Deep learning-based quantification of abdominal fat on magnetic resonance images.
PloS one
Sep 20, 2018
Obesity is increasingly prevalent and associated with increased risk of developing type 2 diabetes, cardiovascular diseases, and cancer. Magnetic resonance imaging (MRI) is an accurate method for determination of body fat volume and distribution. How...
Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE mice.
Biomedical engineering online
Dec 28, 2016
BACKGROUND: This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of plaque to generate predictiv...
Magnetic Resonance Imaging
Blood Flow Velocity
Predictive Value of Tests
Apolipoproteins E
Mice, Transgenic
Mice, Inbred C57BL
Machine Learning
Disease Progression
Ultrasonography, Doppler
Decision Making
Sensitivity and Specificity
Algorithms
Ultrasonography
Lipids
Carotid Arteries
Animals
Reproducibility of Results
Mice
Plaque, Atherosclerotic
Male
Support Vector Machine
Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice.
Canadian journal of physiology and pharmacology
Dec 22, 2016
Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE) mice. In vitro, p...
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