Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning.

Journal: Frontiers in immunology
PMID: 40191191

Abstract

BACKGROUND: Recent studies have suggested a potential association between gastric cancer (GC) and myocardial infarction (MI), with shared pathogenic factors. This study aimed to identify these common factors and potential pharmacologic targets.

Authors

  • Junyang Ma
    School of Clinical Medicine, Jining Medical University, Jining, China.
  • Shufu Hou
    Laboratory of Metabolism and Gastrointestinal Tumor, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
  • Xinxin Gu
    Jinzhou Medical University, Shanghai Fengxian District Central Hospital Postgraduate Training Base, Shanghai, China.
  • Peng Guo
    Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
  • Jiankang Zhu
    Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong, China.

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