Machine Learning to Predict Mortality in Older Patients With Cancer: Development and External Validation of the Geriatric Cancer Scoring System Using Two Large French Cohorts.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PMID: 39854651

Abstract

PURPOSE: Establishing an accurate prognosis remains challenging in older patients with cancer because of the population's heterogeneity and the current predictive models' reduced ability to capture the complex interactions between oncologic and geriatric predictors. We aim to develop and externally validate a new predictive score (the Geriatric Cancer Scoring System [GCSS]) to refine individualized prognosis for older patients with cancer during the first year after a geriatric assessment (GA).

Authors

  • Etienne Audureau
    INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.
  • Pierre Soubeyran
    Department of Medical Oncology, Institut Bergonié, Inserm U1218, Université de Bordeaux, Bordeaux, France.
  • Claudia Martinez-Tapia
    INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.
  • Carine Bellera
    INSERM U1219, Bordeaux Public Health, University of Bordeaux, Bordeaux, France.
  • Sylvie Bastuji-Garin
    INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.
  • Pascaline Boudou-Rouquette
    Department of Medical Oncology, Hôpital Cochin, AP-HP, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France.
  • Anne Chahwakilian
    Gerontology 1 Department, AP-HP, Broca Hospital, Paris, France.
  • Thomas Grellety
    Medical Oncology Department, Centre Hospitalier de la Côte Basque, Bayonne, France.
  • Olivier Hanon
    Université Paris-Descartes, EA 4468, Hôpital Broca, APHP, Gérontopôle d'Ile-de-France Paris, France.
  • Simone Mathoulin-Pélissier
    Bordeaux Population Health Research Center, Epicene Team, UMR 1219, Inserm, Univ. Bordeaux, Bordeaux, France.
  • Elena Paillaud
    INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.
  • Florence Canouï-Poitrine
    INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.

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