Machine learning localization to identify the epileptogenic side in mesial temporal lobe epilepsy.

Journal: Magnetic resonance imaging
PMID: 39426692

Abstract

BACKGROUND: Mesial temporal sclerosis (MTS) is the most common pathology associated with drug-resistant mesial temporal lobe epilepsy (mTLE) in adults. Most atrophic hippocampi can be identified using MRI based on standard epilepsy protocols; however, difficulties can arise in cases where sclerotic changes in the hippocampus are subtle or non-epilepsy-specific protocols have been implemented. In such cases, quantitative methods, such as T1-weighted axial series MRIs, are valuable additional tools to complement epilepsy-specific protocols. In the current study, we applied machine learning (ML) techniques to the analysis of brain regions of interest (ROIs), including the hippocampus, thalamus, and cortical areas, to enhance the accuracy of lesion lateralization in MRI.

Authors

  • Hsiang-Yu Yu
    Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Cheng Jui Tsai
    Department of General Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  • Tse-Hao Lee
    School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Hsin Tung
    Center of faculty development, Taichung Veterans General Hospital, Taichung, Taiwan; Division of Epilepsy, Neurological Institute, Taichung Veterans Gen, Taipei Veterans General Hospitaleral Hospital, Taichung, Taiwan.
  • Yen-Cheng Shih
    Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Chien-Chen Chou
    Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Cheng-Chia Lee
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
  • Po-Tso Lin
    Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Syu-Jyun Peng
    Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsin-Chu, Taiwan; Institute of Electronics, National Chiao Tung University, Hsin-Chu, Taiwan. Electronic address: blue.year@msa.hinet.net.

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