Identification of genomic alteration and prognosis using pathomics-based artificial intelligence in oral leukoplakia and head and neck squamous cell carcinoma: a multicenter experimental study.

Journal: International journal of surgery (London, England)
PMID: 39248300

Abstract

BACKGROUND: Loss of chromosome 9p is an important biomarker in the malignant transformation of oral leukoplakia (OLK) to head and neck squamous cell carcinoma (HNSCC), and is associated with the prognosis of HNSCC patients. However, various challenges have prevented 9p loss from being assessed in clinical practice. The objective of this study was to develop a pathomics-based artificial intelligence (AI) model for the rapid and cost-effective prediction of 9p loss (9PLP).

Authors

  • Xin-Jia Cai
    Central Laboratory, Peking University School and Hospital of Stomatology.
  • Chao-Ran Peng
    National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices.
  • Ying-Ying Cui
    National Center of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices.
  • Long Li
    Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.
  • Ming-Wei Huang
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No.22, Zhongguancun South Avenue, Haidian District, Beijing 100081, China. Electronic address: hmwd97@126.com.
  • He-Yu Zhang
    Central Laboratory, Peking University School and Hospital of Stomatology.
  • Jian-Yun Zhang
    Beijing Key Laboratory of Digital Stomatology,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,National Clinical Research Center for Oral Diseases,Beijing 100081,China.
  • Tie-Jun Li
    Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.

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