Identification of potential biomarkers in cardiovascular calcification based on bioinformatics combined with single-cell RNA-seq and multiple machine learning analysis.

Journal: Cellular signalling
PMID:

Abstract

BACKGROUND: The molecular and genetic mechanisms underlying vascular calcification remain unclear. This study aimed to determine the differences in calcification marker-related gene expression in macrophages.

Authors

  • Bingchen Guo
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China. Electronic address: gbc96dr@163.com.
  • Si Shi
    Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong'An Road, Shanghai, 200032, People's Republic of China. shisi@fudanpci.org.
  • Jie Xiong
    Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Laboratory Medicine, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, China.
  • Yutong Guo
    Department of Orthodontics, State Key Laboratory of Oral Diseases, West China School of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  • Bo Wang
    Department of Clinical Laboratory Medicine Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China.
  • Liyan Bai
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
  • Yi Qiu
    Orthopedic Ward Four, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu, China.
  • Shucheng Li
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
  • Dianyu Gao
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
  • Zengxiang Dong
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China.
  • Yingfeng Tu
    Harbin Medical University, Harbin, China; Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China; Department of Cardiology, The Shanxi Provincial People's Hospital, Taiyuan 030000, China. Electronic address: tyfdoctor@163.com.