Estimation of Ganciclovir Exposure in Adults Transplant Patients by Machine Learning.

Journal: The AAPS journal
PMID: 40021573

Abstract

INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads to overexposure or underexposure. This study aimed to train, test and validate machine learning (ML) algorithms for accurate GCV AUC0-24 h estimation in solid organ transplantation.

Authors

  • Hamza Sayadi
    Department of Pharmacology, Toxicology and Pharmacovigilance, CHU de Limoges, Limoges, France.
  • Yeleen Fromage
    Service de Pharmacologie, Toxicologie et Pharmacovigilance, CHU Dupuytren, Limoges, France.
  • Marc Labriffe
    University of Limoges, IPPRITT, Limoges, France.
  • Pierre-André Billat
    INERIS, Experimental Toxicology and Modeling Unit (TEAM), Parc ALATA BP2, Verneuil en Halatte, France.
  • Cyrielle Codde
    Service de Maladies Infectieuses et Tropicales, CHU Dupuytren, Limoges, France.
  • Selim Arraki Zava
    Department of Pharmacology, Toxicology and Pharmacovigilance, CHU de Limoges, Limoges, France.
  • Pierre Marquet
    University of Limoges, UMR 1248.
  • Jean-Baptiste Woillard
    P&T, Unité Mixte de Recherche 1248 Université de Limoges, Institut National de la Santé et de la Recherche Médicale, Limoges, France.

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