AIMC Topic: Valganciclovir

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Estimation of Ganciclovir Exposure in Adults Transplant Patients by Machine Learning.

The AAPS journal Feb 28, 2025
INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads t...
Area Under Curve Organ Transplantation Adult Antiviral Agents Creatinine Valganciclovir Ganciclovir Cytomegalovirus Infections Models, Biological Humans Machine Learning Algorithms Computer Simulation
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Application of machine-learning models to predict the ganciclovir and valganciclovir exposure in children using a limited sampling strategy.

Antimicrobial agents and chemotherapy Aug 28, 2024
Intravenous ganciclovir and oral valganciclovir display significant variability in ganciclovir pharmacokinetics, particularly in children. Therapeutic drug monitoring currently relies on the area under the concentration-time (AUC). Machine-learning (...
Child Antiviral Agents Adolescent Child, Preschool Drug Monitoring Cytomegalovirus Infections Area Under Curve Bayes Theorem Algorithms Female Male Infant Humans Machine Learning Valganciclovir Ganciclovir Administration, Oral Administration, Intravenous
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Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning.

Clinical pharmacokinetics Mar 16, 2024
BACKGROUND AND OBJECTIVES: Ganciclovir (GCV) and valganciclovir (VGCV) show large interindividual pharmacokinetic variability, particularly in children. The objectives of this study were (1) to develop machine learning (ML) algorithms trained on simu...
Valganciclovir Ganciclovir Machine Learning Algorithms Computer Simulation Female Humans Child Antiviral Agents Adolescent Models, Biological Child, Preschool Monte Carlo Method Male Area Under Curve Infant
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Predictive factors of spontaneous CMV DNAemia clearance in kidney transplantation.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Dec 29, 2017
UNLABELLED: Cytomegalovirus (CMV) infection occurs frequently after solid organ transplantation. Therapeutic strategies, in particular when to start a curative treatment, has not yet been defined. The purpose of this study was to assess predictive fa...
Valganciclovir Polymerase Chain Reaction Tissue Donors Antibiotic Prophylaxis DNA, Viral ROC Curve Antiviral Agents Cytomegalovirus Infections Serologic Tests Follow-Up Studies Cytomegalovirus Female Aged Male Middle Aged Prospective Studies Humans Retrospective Studies Kidney Transplantation
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