AIMC Topic: Ganciclovir

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Estimation of Ganciclovir Exposure in Adults Transplant Patients by Machine Learning.

The AAPS journal Feb 28, 2025
INTRODUCTION: Valganciclovir, a prodrug of ganciclovir (GCV), is used to prevent cytomegalovirus infection after transplantation, with doses adjusted based on creatinine clearance (CrCL) to target GCV AUC0-24 h of 40-60 mg*h/L. This sometimes leads t...
Humans Machine Learning Algorithms Computer Simulation Adult Antiviral Agents Area Under Curve Organ Transplantation Cytomegalovirus Infections Models, Biological Creatinine Valganciclovir Ganciclovir
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Application of machine-learning models to predict the ganciclovir and valganciclovir exposure in children using a limited sampling strategy.

Antimicrobial agents and chemotherapy Aug 28, 2024
Intravenous ganciclovir and oral valganciclovir display significant variability in ganciclovir pharmacokinetics, particularly in children. Therapeutic drug monitoring currently relies on the area under the concentration-time (AUC). Machine-learning (...
Humans Machine Learning Algorithms Female Male Infant Adolescent Child, Preschool Child Antiviral Agents Area Under Curve Bayes Theorem Drug Monitoring Cytomegalovirus Infections Administration, Oral Administration, Intravenous Valganciclovir Ganciclovir
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Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning.

Clinical pharmacokinetics Mar 16, 2024
BACKGROUND AND OBJECTIVES: Ganciclovir (GCV) and valganciclovir (VGCV) show large interindividual pharmacokinetic variability, particularly in children. The objectives of this study were (1) to develop machine learning (ML) algorithms trained on simu...
Humans Machine Learning Algorithms Computer Simulation Female Male Infant Adolescent Child, Preschool Child Antiviral Agents Area Under Curve Models, Biological Monte Carlo Method Valganciclovir Ganciclovir
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