Characterizing Brain-Cardiovascular Aging Using Multiorgan Imaging and Machine Learning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
PMID: 39971581

Abstract

The structure and function of the brain and cardiovascular system change over the lifespan. In this study, we aim to establish the extent to which age-related changes in these two vital organs are linked. Utilizing normative models and data from the UK Biobank, we estimate biological ages for the brain and heart for 2,904 middle-aged and older healthy adults, including both males and females. Biological ages were based on multiple structural, morphological, and functional features derived from brain and cardiovascular imaging modalities. We find that cardiovascular aging, particularly aging of its functional capacity and physiology, is selectively associated with the aging of specific brain networks, including the salience, default mode, and somatomotor networks as well as the subcortex. Our work provides unique insight into brain-heart relationships and may facilitate an improved understanding of the increased co-occurrence of brain and heart diseases in aging.

Authors

  • Yalda Amirmoezzi
    Department of Medical Physics and Engineering, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Vanessa Cropley
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria, Australia.
  • Sina Mansour L
    Systems Lab, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria 3010, Australia.
  • Caio Seguin
    Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, 3010, Australia.
  • Andrew Zalesky
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia.
  • Ye Ella Tian
    Systems Lab, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria 3010, Australia.

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