Identification of benzo(a)pyrene-related toxicological targets and their role in chronic obstructive pulmonary disease pathogenesis: a comprehensive bioinformatics and machine learning approach.

Journal: BMC pharmacology & toxicology
PMID:

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) pathogenesis is influenced by environmental factors, including Benzo(a)pyrene (BaP) exposure. This study aims to identify BaP-related toxicological targets and elucidate their roles in COPD development.

Authors

  • Jiehua Deng
    Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025 Shennan Zhong Lu, Shenzhen City, Guangdong Province, 518033, China.
  • Lixia Wei
    Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025 Shennan Zhong Lu, Shenzhen City, Guangdong Province, 518033, China. weilx004011@aliyun.com.
  • Yongyu Chen
    Department of Medical Ultrasonics, The First People's Hospital of Foshan, No. 81, Lingnan Avenue North, Foshan, 528000, China.
  • Xiaofeng Li
    Department of Otorhinolaryngology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
  • Hui Zhang
    Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Xuan Wei
    Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 100050, People's Republic of China.
  • Xin Feng
    State Key Laboratory for Zoonotic Diseases, College of Veterinary Medicine, Jilin University, Changchun, China.
  • Xue Qiu
    College of Computer and Information Science, Chongqing Normal University, Chongqing, China.
  • Bin Liang
    Image Processing Center, Beihang University, Beijing 100191, People's Republic of China. Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People's Republic of China.
  • Jianquan Zhang
    Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, 3025 Shennan Zhong Lu, Shenzhen City, Guangdong Province, 518033, China. jqzhang2002@126.com.