AIMC Topic: Benzo(a)pyrene

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Integrated transcriptomics and proteomics reveal ferroptosis induced by B[a]P and BPDE in mouse hippocampal neurons.

Scientific reports
The environmental pollutant Benzo[a]pyrene (B[a]P) and its ultimate metabolite B[a]P-7,8-diol-9,10-epoxide (BPDE) exhibit neurotoxic effects, yet the underlying molecular mechanisms remain enigmatic. Recently, ferroptosis has emerged as a potential p...

Identification of benzo(a)pyrene-related toxicological targets and their role in chronic obstructive pulmonary disease pathogenesis: a comprehensive bioinformatics and machine learning approach.

BMC pharmacology & toxicology
BACKGROUND: Chronic obstructive pulmonary disease (COPD) pathogenesis is influenced by environmental factors, including Benzo(a)pyrene (BaP) exposure. This study aims to identify BaP-related toxicological targets and elucidate their roles in COPD dev...

Influence of Industrialization and Environmental Protection on Environmental Pollution: A Case Study of Taihu Lake, China.

International journal of environmental research and public health
In order to quantitatively study the effect of environmental protection in China since the twenty-first century and the environmental pollution projected for the next ten years (under the model of extensive economic development), this paper establish...

Refining source-specific lung cancer risk assessment from PM-bound PAHs: Integrating component-based potency factors and machine learning in Ningbo, China.

Ecotoxicology and environmental safety
The component-based potency factor approach, combined with benzo[a]pyrene (BaP) unit risk values from the World Health Organization (WHO), is commonly used to assess lung excess cancer risk (LECR) from polycyclic aromatic hydrocarbons (PAHs). However...