Identification of Depression Subtypes in Parkinson's Disease Patients via Structural MRI Whole-Brain Radiomics: An Unsupervised Machine Learning Study.

Journal: CNS neuroscience & therapeutics
PMID:

Abstract

OBJECTIVE: Current clinical evaluation may tend to lack precision in detecting depression in Parkinson's disease (DPD). Radiomics features have gradually shown potential as auxiliary diagnostic tools in identifying and distinguishing different subtypes of Parkinson's disease (PD), and a radiomic approach that combines unsupervised machine learning has the potential to identify DPD.

Authors

  • Zihan Zhang
  • Jiaxuan Peng
    Jinzhou Medical University, Jinzhou, Liaoning Province, China.
  • Qiaowei Song
    Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Yuyun Xu
  • Yuguo Wei
    Precision Health Institution, GE Healthcare, Xihu District, Hangzhou, China.
  • Zhenyu Shu
    Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou.