Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab.

Journal: Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
PMID: 40317378

Abstract

BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine diagnostic marker, while H3F3A mutational analysis enhances prognostic insights. Treatment primarily involves surgical methods such as curettage or en bloc resection, with denosumab serving as an adjunct in high-risk or inoperable cases.

Authors

  • Jasminka Igrec
    Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8010, Graz, Austria. jasminka.igrec@medunigraz.at.
  • Lisa Jernej
    Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
  • Maria Anna Smolle
    Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
  • Jakob Steiner
    Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8010, Graz, Austria.
  • Susanne Scheipl
    Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
  • Birgit Lohberger
    Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria.
  • Andreas Leithner
    Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria.
  • Iva Brcic
    D&R Institute of Pathology, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria. iva.brcic@medunigraz.at.

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