AIMC Topic: Denosumab

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Effects of bisphosphonates after denosumab discontinuation and treatment effect heterogeneity using causal machine learning.

Scientific reports Dec 24, 2025
Discontinuation of denosumab is associated with a rebound increase in osteoporotic fracture (OF) risk, and bisphosphonates (BPs) are commonly recommended as sequential therapy to mitigate this risk. However, their real-world effectiveness-and whether...
Humans Machine Learning Retrospective Studies Osteoporosis Republic of Korea Female Aged Aged, 80 and over Male Middle Aged Treatment Outcome Denosumab Bone Density Conservation Agents Osteoporotic Fractures Treatment Effect Heterogeneity Diphosphonates
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Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology May 3, 2025
BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine ...
Humans Prognosis Retrospective Studies Female Young Adult Adult Male Middle Aged Bone Neoplasms Neoplasm Grading Mutation Denosumab Bone Density Conservation Agents Histones Giant Cell Tumor of Bone Curettage
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Evaluating the Effect of Denosumab in Preventing Anchorage Loss: A Split-mouth Randomized Controlled Trial.

The journal of contemporary dental practice Dec 1, 2021
AIM: The trial was focused on assessing the effect of Denosumab in preventing anchorage loss during en-masse anterior retraction and evaluating its effect on the retraction.
Humans Cephalometry Mouth Denosumab Orthodontic Anchorage Procedures Tooth Movement Techniques
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