Deep structural brain imaging via computational three-photon microscopy.

Journal: Journal of biomedical optics
PMID:

Abstract

SIGNIFICANCE: High-resolution optical imaging at significant depths is challenging due to scattering, which impairs image quality in living matter with complex structures. We address the need for improved imaging techniques in deep tissues.

Authors

  • Lingmei Chen
    Zhejiang University, College of Optical Science and Engineering, International Research Center for Advanced Photonics, State Key Laboratory of Extreme Photonics and Instrumentation, Hangzhou, China.
  • Mubin He
    Zhejiang University, College of Optical Science and Engineering, International Research Center for Advanced Photonics, State Key Laboratory of Extreme Photonics and Instrumentation, Hangzhou, China.
  • Lu Yang
    Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lingxi Zhou
    Department of Computer Science and Engineering, University of South Carolina, Columbia, 29208, South Carolina, USA.
  • Shuhao Qian
    State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • Chuncheng Wang
    Zhejiang University, College of Optical Science and Engineering, International Research Center for Advanced Photonics, State Key Laboratory of Extreme Photonics and Instrumentation, Hangzhou, China.
  • Rushan Jiang
    Zhejiang University, College of Optical Science and Engineering, International Research Center for Advanced Photonics, State Key Laboratory of Extreme Photonics and Instrumentation, Hangzhou, China.
  • Zhihua Ding
    Zhejiang University, College of Optical Science and Engineering, International Research Center for Advanced Photonics, State Key Laboratory of Extreme Photonics and Instrumentation, Hangzhou, China.
  • Jun Qian
    State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences, Soochow University, 215123 Suzhou, China.
  • Zhiyi Liu
    Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.