Artificial intelligence-based virtual staining platform for identifying tumor-associated macrophages from hematoxylin and eosin-stained images.

Journal: European journal of cancer (Oxford, England : 1990)
PMID: 40158294

Abstract

BACKGROUND: Virtual staining is an artificial intelligence-based approach that transforms pathology images between stain types, such as hematoxylin and eosin (H&E) to immunohistochemistry (IHC), providing a tissue-preserving and efficient alternative to traditional IHC staining. However, existing methods for translating H&E to virtual IHC often fail to generate images of sufficient quality for accurately delineating cell nuclei and IHC+ regions. To address these limitations, we introduce VISTA, an artificial intelligence-based virtual staining platform designed to translate H&E into virtual IHC.

Authors

  • Arpit Aggarwal
    Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
  • Mayukhmala Jana
    Department of Biomedical Engineering, Georgia Tech, GA, USA; Department of Biomedical Engineering, Emory University, GA, USA.
  • Amritpal Singh
    Department of Electrical Engineering, I K G Punjab Technical University, Jalandhar, Punjab, India.
  • Tanmoy Dam
    Department of Biomedical Engineering, Emory University, GA, USA.
  • Himanshu Maurya
    Department of Biomedical Engineering, Emory University, GA, USA.
  • Tilak Pathak
    Emory Winship Cancer Institute, Atlanta, GA, USA.
  • Sandra Orsulic
    Greater Los Angeles Veterans Administration, CA, USA.
  • Kailin Yang
    Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Deborah Chute
    Cleveland Clinic Foundation, Cleveland, Ohio, USA.
  • Justin A Bishop
    University of Texas (UT) Southwestern Medical Center, Dallas, Texas, USA.
  • Farhoud Faraji
    UCSD, San Diego, California, USA.
  • Wade M Thorstad
    Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MS, USA.
  • Shlomo Koyfman
    Cleveland Clinic Foundation, Cleveland, Ohio, USA.
  • Scott Steward
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GA, USA.
  • Qiuying Shi
    Department of Pathology, Emory University Hospital Midtown, Atlanta, GA, USA.
  • Vlad Sandulache
    Department of Otolaryngology, Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
  • Nabil F Saba
    Department of Hematology and Medical Oncology, The Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • James S Lewis
    Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • German Corredor
    Universidad Nacional de Colombia, Bogotá D.C, Colombia.
  • Anant Madabhushi
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

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